Bristol-Myers Squibb is a global biopharmaceutical company whose mission is to discover, develop and deliver innovative medicines that help patients prevail over serious diseases.
One shared journey is moving us forward at Bristol-Myers Squibb.
Around the world, we are passionate about making an impact on the lives of patients with serious disease.
Empowered to apply our individual talents and ideas so that we can learn and grow together.
And driven to make a difference, from innovative research to hands-on community support.
Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment.
We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.
Among our several NJ locations, our Hopewell and Bloomsbury sites are key components of the Biologics Network Strategy, with available Process Development and Analytical Development & Testing opportunities to support the innovating biologics under development.
In the Molecular and Analytical Development group of BMS, we are a world-class Mass Spectrometry and Biophysics Center of Excellence to support the development of life-saving medicines in immuno-oncology and other therapeutic areas.
We specialize in biologics development using state of the art biophysical methods to decipher the structural complexities of biological molecules.
We foster an innovative and collaborative environment that values and recognizes diversity of contributions, and pushing the limits of technology for analyzing monoclonal antibodies, fusion proteins, and other novel scaffolds progressing in clinical trials for unmet medical needs.
The Molecular and Analytical Development group is seeking a highly motivated and creative Biophysical Scientist to analyze structure, stability, and post-translational modifications to support development of biopharmaceuticals, and be part of the leadership position of BMS in Immuno-Oncology.
This individual is also expected to push the limits of advanced biophysical techniques for characterization of fusion proteins, therapeutic monoclonal antibodies and other protein modalities.
These techniques include, but are not limited to:
Spectroscopy (UV/VIS, CD, fluorescence, FTIR, Raman)Microscopy (FTIR, Raman, AFM) Flow-based protein particulate imaging and enumeration Light obscuration and other protein particulate characterization/enumeration techniquesAnalytical ultracentrifugation Calorimetry (DSC, ITC) Chromatography (SEC, IEX, RP) Capillary electrophoresis (iCIEF, SDS-CGE) Additional responsibilities include:
Defining critical quality attributes and understanding protein post-translational modifications including degradation pathways in in-vitro systemsExpected to publish novel findings in journals and present scientific data at internal and external conferencesMatrix team leadershipWork independently and in collaboration with colleagues within analytical and across various functional areas to support programs from clinical development through registrational studiesInterface and collaborate with multi-disciplinary teams in a high paced analytical laboratory environment Qualifications We look for scientists who are truly inspired by our mission and who would share our passion for collaborative and entrepreneurial work culture.
Because we know that employees are key to our success in bringing novel cancer medicines to patients, we are committed to providing employees with benefits that allow them to bring their best.
Minimum Requirements:
PhD in biophysics, biochemistry, physical chemistry, pharmaceutical science or a related scientific discipline with 0-4 years of relevant experience in biopharmaceutical/ biotechnology, or a Masters with a minimum of 5 years of relevant experience is requiredAn ideal candidate would have experience with therapeutic proteins including mAb, bispecific antibodies, fusion proteins, antibody drug conjugates and other derivatized proteins, and their structure-function relationshipsKnowledge of protein chemistry, structure, function, and folding are essentialDemonstrated skills and proficiency in biophysical techniques including operation, maintenance and trouble shootingFamiliarity with protein higher order structure analysis, protein particulate techniques such as flow imaging as well as microscopy is a plusExcellent communication, interpersonal and organizational skills are essentialAttention to detail and be able to work in a highly collaborative environment under tight timelinesProven track record of independent research capability and problem solving ability is required Bristol-Myers Squibb is an equal opportunity employer - Vet/Disability - 1501866

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